This course integrates the principles and methods of engineering and life sciences towards the fundamental understanding of structure-function relationships in normal and pathological mammalian tissues. The course gives an introduction to how devices are designed. Concepts of design of biomaterials systems for the intended applications with the evolving paradigm of biocompatibility will be elucidated. Guiding biomechanical principles required for these designs will also be covered. Students will also be exposed to future strategies involving nanotechnology and regenerative medicine concepts. The translation process of how devices are tested and transformed into market will be discussed. Students will learn the process of assessment of clinical need/market, select the optimal treatment strategy and decide on the particular design factors of a medical device which need to be considered for a particular application.