The Biggs Lab at NUI Galway
Welcome to the Biggs Lab Homepage. The Biggs group conducts multi-disciplinary bioengineering research at the National University of Ireland, Galway to develop biomaterials focused solutions to medical device design with a focus on the nanofabrication of electrically active and responsive biomaterials.
World Biomaterials Congress
11/12/2020 - 15/12/2020
GRC meeting Biomaterials and Tissue Engineering
18/07/2021 - 23/07/2021
Holderness - USA
EMRS Annual Meeting 2020
BIGGS LAB NEWS
New Collaborative Paper with Matthew Dalby and Team on Nanovibrational Stimulation of Stem Cells
There is a pressing clinical need to develop cell-based bone therapies due to a lack of viable, autologous bone grafts and a growing demand for bone grafts in musculoskeletal surgery. Such therapies can be tissue engineered and cellular, such as osteoblasts combined with a material scaffold. Because mesenchymal stem cells (MSCs) are both available and fast growing compared to mature osteoblasts, therapies that utilise these progenitor cells are particularly promising. Prof.. Matthew Dalby and team at the University of Glasgow have developed a nanovibrational bioreactor that can convert MSCs into bone-forming osteoblasts in 2D and 3D but the mechanisms involved in this osteoinduction process remain unclear. In this study, to elucidate this mechanism, we worked with Prof. Dalby with increasing vibrational amplitudes, from 30 nm (N30) to 90 nm (N90) amplitudes at 1000 Hz, to assess MSC metabolite, gene and protein changes.
Alexandre Trotier Receives a Best Rapid-Fire Presentation Award at Frontiers in Traumatic Brain Injury Meeting 2020
The Frontiers in Traumatic Brain Injury 2020 (FiTBI2020) conference was hosted online on the 16th of June 2020 to showcase the current developments in the world of traumatic brain injury (TBI) research.
TBI is a multidisciplinary problem and this conference was initiated to bring together clinicians and scientists, from all disciplines, to be informed on, and contribute to discussions surrounding the latest advances in TBI science. This year the online conference has welcomed well over a thousand attendees from countries all over the world, and is still getting more today from delegates signing in to watch the replays.
Alexandre Trotier was awarded the Best presentation in the rapid-fire session for his talk on the activation of ion channel mechanosensors in a novel glial scar in vitro model
Dr Adriona Kelly Awarded the Ph.D Degree Following a Successful Thesis Defence
Adriona Kelly was awarded the Ph.D degree after successfully defending her thesis on February 28th, 2020. Adriona was co-supervised by Prof Ger O'Connor and was examined by Dr Una Fitzgerald (NUI Galway) and Dr Mathis Riehle (University of Glasgow). Adriona has been a member of the Biggs Lab since 2013, when she initiated Ph.D studies into laser processing of platinum alloys, submitting a thesis entitled 'Fabrication of Biomimetic Electrodes by Laser Processing and Two Photon Lithography'. Adriona has initiated a senior research engineer position at a medtech company in Galway. All the Biggs Lab wish her the very best and look forward to hearing of her continued success.
Funding Awarded For EPSRC-SFI 2018 Centre for Doctoral Training - LifETIME (Engineered Tissues for Discovery, Industry and Medicine)
Funding has been approved by SFI and the EPSRC for an new centre for doctoral training (CDT), a partnership between the University of Glasgow, the University of Birmingham, Aston University and CÚRAM. SFI has agreed to fund 25 PhD positions, 5 per year for the next 5 years, with the first cohort to be recruited in September 2019. The program will last for eight years.
The lifETIME CDT focuses on development of non-animal technologies to improve predictive power of pre-clinical drug screens and thus drive medicines discovery. In this programme students will undergo a secondment with an industry partner (Pharma, contract research organisations, small enterprises). Also, as the CDT is based at Universities of Glasgow, Birmingham, Aston and CÚRAM we will work with these academic partners to create a national cohort of new talent to drive this sector. Students will be hosted in dynamic labs and will have the opportunity for co-supervision, travel and training within CÚRAM and the UK. The first projects the CDT are currently being formulated by CÚRAM and our UK partners and will be available online soon, the lifETIME CDT website can be accessed at the following address https://lifetime-cdt.org.