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PUBLICATIONS

Journal Publications

2021​

  1. Fernandez-Yague MA, Trotier A, Abbah SA, Larra A, Thirumaran A, Stapleton A, Tofail SA, Palma M, Pandit A, *Biggs MJP. ‘A self-powered piezo-bioelectric device mediates tendon repair through modulation of mechanosensitive ion channels’ Advanced Materials 2021, In Press. DOI: 10.1002/adma.202008788

  2. Ryan CNM, Shologu N, Islam N, Gaspar D, Rooney P, O’Riordan A, Biggs MJ, Griffin MD, Zeugolis DI. ‘A combined physicochemical approach towards human tenocyte phenotype maintenance’. Materials Today Bio 2021 In Press. DOI: 10.1016/j.mtbio.2021.100130

  3. Turner B, Senevirathne S, Kilgour K, McArt D, Biggs M, Menegatti S, Daniele MA. ‘Ultrasound-Powered Implants: A Critical Review of Piezoelectric Material Selection and Applications’ Advanced Healthcare Materials 2021, 2100986

  4. Suku M, Forrester L, Biggs M, Monaghan MG. ‘Resident macrophages – a potential gamechanger in cardiac tissue engineering?’ Tissue Engineering Part B 2021, in Press, DOI:10.1089/ten.TEB.2021.0036

  5. Britton J, Krukiewicz K, Chandran M, Fernandez J, Sarasua JR, Fitzgerald U, *Biggs MJP. ‘Flexible strain-responsive sensors fabricated from a biocompatible electronic ink via additive-manufacturing’ Materials & Design 2021, in Press

  6. Krukiewicz K, Britton J, Więcławska D, Skorupa M, Fernandez J, Sarasua JR, Biggs MJP. 'Electrical percolation in extrinsically conducting, poly(ε-decalactone) composite neural interface material'. Scientific Reports 2021, 11(1), 1-10

  7. Tadayyon G, Krukiewicz K, Britton J, Larrañaga A, Vallejo-Giraldo C, Fernandez-Yague M, Guo Y, Orpella-Aceret G, Li L, Poudel A, Biggs MJP. 'In vitro analysis of a physiological strain sensor formulated from a PEDOT:PSS functionalized carbon nanotube-poly(glycerol sebacate urethane) composite'. Materials Science & Engineering C 2021, 121, 111857

  8. Vallejo-Giraldo C, Krukiewicz K, *Biggs MJ, ‘Towards a Mechanobiological Understanding of Gliosis’ Advanced NanoBiomed Research 2021, in press

2020​

  1. Krukiewicz K, Kobud D, Turczyn R, Erfurt K, Chrobok A, Biggs MJ, 'Low resistance, highly corrugated structures based on poly (3, 4-ethylenedioxythiophene) doped with a d-glucopyranoside-derived ionic liquid' Electrochemistry Communications 2020: 110, 106616

  2. Krukiewicz K, Kowalik A, Turczyn R, Biggs MJP. 'In vitro attenuation of astrocyte activation and neuroinflammation through ibuprofen-doping of poly (3, 4-ethylenedioxypyrrole) formulations'. Bioelectrochemistry 2020, 107528

  3. Kelly A, Farid N, Krukiewicz K, Belisle N, Groarke J, Waters EM, Trotier A, Biggs MJP. 'Laser-Induced Periodic Surface Structure Enhances Neuroelectrode Charge Transfer Capabilities and Modulates Astrocyte Function. ACS Biomaterials Science & Engineering 2020, 6 (3), 1449-1461

  4. Oripiriyakul W, Tsimbouri M, Childs P, Campsie P, Wells J, Fernandez MM, Burgess K, Tanner E, Tassieri M, Meek D, Vassall Mi, Biggs MJ,l Salmeron-Sanchez M, Oreffo R, Reid S, Dalby M. 'Nanovibrational stimulation of mesenchymal stem cells induces therapeutic reactive oxygen species and inflammation for 3D bone tissue engineering'. ACS Nano 2020, (in press)

  5. Sadaba N, Larrañaga A, Orpella-Aceret G, Bettencourt AF, Martin V, Biggs MJ, Ribeiro IAC, Ugartemendia JM,  Sarasua JR,  Zuza E. 'Benefits of Polydopamine as Particle/Matrix Interface in Polylactide/PD-BaSO4 Scaffolds'. International journal of molecular sciences 2020 21 (15), 5480

2019​​​

  1. Fernandez-Yague MA, Antoñanzas RP, Roa JJ, Biggs MJ, Gil FJ, Pegueroles M. ‘Enhanced osteoconductivity on electrically charged titanium implants treated by physicochemical surface modifications methods’ Nanomedicine:Nanotechnology, Biology and Medicine 2019 (In Press)

  2. Krukiewicz K, Kowalik A, Czerwińska-Główka D, Biggs MJ, ‘Electrodeposited poly (3, 4-ethylenedioxypyrrole) films as neural interfaces: Cytocompatibility and electrochemical studies’ Electrochimica Acta 2019: (In Press)

  3. Krukiewicz K, Chudy M, Gregg S, Biggs MJ. ‘The Synergistic Effects of Gold Particles and Dexamethasone on the Electrochemical and Biological Performance of PEDOT Neural Interfaces’ . Polymers 2019: 11(1), 67-70

  4. Krukiewicz K, Janas D, Vallejo Giraldo C, Biggs MJ,  ‘Self-supporting carbon nanotube films as flexible neural interfaces’ Electrochimica Acta 2019: 295, 253-261

  5. Krukiewicz K, Fernandez J, Skorupa M, Więcławska D, Poudel A, Sarasua JR, Quinlan LR *Biggs MJ. ‘Analysis of a poly(ε-decalactone)/silver nanowire composite as an electrically conducting neural interface biomaterial’ BMC Biomedical Engineering 2019 1:9

  6. Poudel A, Fernandez MA, Tofail SA, Biggs MJ. 'Boron nitride nanotube addition enhances the crystallinity and cytocompatibility of PVDF-TrFE' Frontiers in chemistry 2019 7, 364

  7. Solazzo M, Krukiewicz K, Zhussupbekova A, Fleischer K, Biggs M, Monaghan M. 'PEDOT: PSS interfaces stabilised using a PEGylated crosslinker yield improved conductivity and biocompatibility' Journal of Materials Chemistry B. 2019

​

2018​​

  1. Pereira DR, Oliveira JM, Reis RL, Pandit A, Biggs MJ. ‘Nanocellulose reinforced gellan gum hydrogels as potential biological substitutes for annulus fibrosus tissue regeneration’. Nanomedicine 2018: 14: 3. 897-908

  2. Krukiewicz K, * Biggs MJ, Janas D. ‘Chirality-Sorted Carbon Nanotube Films as High Capacity Electrode Materials’. RSC Advances2018:  8 (53), 30600-30609

  3. Krukiewicz K, Chudy M, Vallejo-Giraldo C, Skorupa M, Więcławska D, Turczyn R, * Biggs MJ.‘Fractal form PEDOT/Au Assemblies as Thin-Film Neural Interface Materials’. Biomedical Materials 2018: 13 (5), 054102

  4. Vallejo-Giraldo C, Krukiewicz K, Calaresu I, Zhu J, Palma M, Fernandez M, McDowell B, Peixoto N, Nazar F, O'Connor G, Ballerini L, Pandit A, * Biggs MJ. ‘Attenuated Glial Reactivity on Topographically Functionalized Poly(3,4‐Ethylenedioxythiophene):P‐Toluene Sulfonate (PEDOT:PTS) Neuroelectrodes Fabricated by Microimprint Lithography’ Small 2018: 14 (28), 1800863

  5. Pandit A, * Biggs MJ, ‘Advanced Functional Materials Solutions to Engineering the Neural Interface’ Advanced Functional Materials2018: 28 (12), 1800827

  6. Vallejo-Giraldo C, Pampaloni N, Pallipurath AR, O’Connell J, Holmes JD, Mokarian-Tabari P, Trotier A, Krukiewicz K, Orpella-Aceret G, Pugliese E, Ballerini L, Kilcoyne M, Dowd E, Quinlan LR, Pandit A, Kavanagh P, Biggs MJ. "Preparation of Cytocompatible ITO Neuroelectrodes with Enhanced Electrochemical Characteristics Using a Facile Anodic Oxidation Process’. Advanced Functional Materials, 2018: 28 (12), 1605035

  7. Tadayyon G, Guo Y, Biggs MJP, Tofail S. 'Deformation Behavior of Heat-Treated Ni-Rich NiTi Shape Memory Alloy'. American Journal of Materials Science and Application 2018: 6 (2), 7-21

2017 ​​​

  1. Biggs MJ, Zeugolis D, Pandit A. 'Foreword to special issue on two-dimensional biomaterials in regenerative medicine'. Nanomedicine (In Press). DOI:10.1016/j.nano.2017.10.005

  2.  McDermott B, McGinley B, Krukiewicz K, Divilly B, Jones M, Biggs M, O'Halloran M, Porter E. ‘Stable Tissue-Mimicking Materials and an Anatomically Realistic, Adjustable Head Phantom for Electrical Impedance Tomography’. Biomedical Physics & Engineering Express (In Press)

  3. Tsimbouri MP, Childs PG, Pemberton GB, Yang J, Jayawarna V, Oripiriyakul W, Burgess K, Gonzalez-Garcia C, Thomas D, Vallejo Giraldo C, Biggs MJ, Curtis ASG, Salmeron-Sanchez  M, Reid S, Dalby MJ. ‘Stimulation of 3D osteogenesis of mesenchymal stem cells using a nanovibrational bioreactor’. Nature Biomedical Engineering 2017: 1, 758–770

  4. Biggs MJ, Fernandez M, Palma M, Cooper R, Liao J, Fazio T, Dahlberg C, Kysar J, Wind SJ. ‘The Functional Response of Mesenchymal Stem Cells to Electron-Beam Patterned Elastomeric Surfaces Presenting Micrometer to Nanoscale Heterogeneous Rigidity’. Advanced Materials, 2017: In Press. Doi:10.1002/adma.201702119

  5. Tsiapalis D, De Pieri A, Biggs M, Pandit A, Zeugolis DI. ‘Biomimetic Bioactive Biomaterials: The Next Generation of Implantable Devices’. ACS Biomaterials Science & Engineering 2017: 3, 1172–1174

  6. Tadayyon G, Guo Y, Mazinani M, Zebarjad S, Tiernan P, Tofail S, Biggs MJ.  ‘Effect of different stages of deformation on the microstructure evolution of Ti-rich NiTi shape memory alloy.’ Materials Characterization 2017:125 51-66

  7. Ryan CNM, Biggs MJ, Pandit A, Zeugolis DI. 'Multifactorial Approaches For Tenogenic Phenotype Maintenance and Function'. Bone Joint J, 2017: 99 38-38

2016

  1. Vallejo Giraldo C, Pugliese E, Larranaga A, Fernandez-Yague M, Britton J, Trotier A, Tadayyon G, Kelly A, Rago L, Sarasua J.R, Dowd E, Quinlan L, Pandit A, Biggs MJ. ‘Polyhydroxyalkanoate/carbon nanotube nanocomposites: flexible electrically conducting elastomers for neural applications.’ Nanomedicine 2016: 11 (19) 2547-2563

  2. Larrañaga A, Pompanon F, Gruffat N, Palomares T, Alonso-Varona A, Larrañaga Varga A, Fernandez-Yague MA, Biggs MJP, Sarasua JR. ‘Effects of isothermal crystallization on the mechanical properties of a elastomeric medium chain length polyhydroxyalkanoate’. European Polymer Journal 2017: 85 401-410

  3. Biggs MJ, Pandit A, Zeugolis D. ‘2D imprinted substrates and 3D electrospun scaffolds revolutionize biomedicine’. Nanomedicine 2016: 11(9), 989-992

  4. Helling A, Tsekoura E, Biggs M, Bayon Y, Pandit A, Zeugolis D. ‘In Vitro Enzymatic Degradation of Tissue Grafts and Collagen Biomaterials by Matrix Metalloproteinases: Improving the Collagenase Assay’. ACS Biomater. Sci. Eng. 2016: (In press) 10.1021/acsbiomaterials.5b00563

  5. Tadayyon G, Mazinani M, Guo Y,  Zebarjad S, Tofail S, Biggs MJ.  ‘The effect of annealing on the mechanical properties and microstructural evolution of Ti-rich NiTi shape memory alloy’. Materials Science and Engineering: A 2016: 662 564-577 

  6. Hardy JG, Palma M, Wind SJ, Biggs MJ. ‘Responsive biomaterials: advances in shape memory polymer-based materials’. Advanced Materials 2016: 28(27) 5717–5724

  7. Tadayyon G, Guo Y, Mazinani M, Zebarjad S, Tofail S, Biggs MJ.  ‘Study of the Microstructure evolution of heat treated Ti-rich NiTi shape memory alloy’. Materials Characterization 2016: 112 11-19 

  8. Fernandez-Yague MA, Zeugolis DI, Pandit A, Biggs MJ. ‘Piezoelectric nanoscaffolds: mediating tendon regeneration through activation of piezoresponsive receptors'. European Cells and Materials 2016: 31, 197-197

  9. Ryan C, Gaspar D, Biggs MJ, Pandit A, Zeugolis DI. 'Multifactorial approaches for cell phenotype maintenance and function' European Cells and Materials 2016: 31, 81-81

  10. Vallejo-Giraldo C, Pandit A, Biggs MJP. 'The Effects of Electrodeposition Current Density on the Morphology, Electrochemical and Biological Characteristics of Poly (3, 4ethylenedioxythiophene): Poly (Styrenesulfonate)(PEDOT-PSS) Neural Interfaces'. IRISH JOURNAL OF MEDICAL SCIENCE 2016; 185, 21-21

  11. Comte C, Fernandez-Yague MA, Quinlan L, Pandit A, Biggs MJP. 'Fabrication of Piezoelectric PVDF TrFE Nanocomposite Scaffolds for Bone-Tissue Engineering'. IRISH JOURNAL OF MEDICAL SCIENCE 2016; 185, 25-25

2015

  1. English A, Azeem A, Biggs M, Jones E, Tripathi B, Basu N, Rooney N, Riley G, O'Riordan A, Cross G, Hutmacher D, Pandit A, Zeugolis DI. 'Substrate topography: A valuable in vitro tool, but a clinical red herring for in vivo tenogenesis’. Acta Biomaterialia 2015: 27: 3-12 

  2. Fernandez-Yague MA, Larrañaga A, Gladkovskaya O, Tadayyon G, Guo Y, SarasuaJR, Pandit A, Syed T, Biggs MJ. ‘Polydopamine Mussel Inspired Functionalization of Boron Nitride Nanotubes (BNNTs) for Improving Dispersion and Cytocompatibility’. Bioconjugate Chemistry 2015: 26(10) 2025-2037

  3. Dalby MJ, Biggs MJ. ‘Special Focus on Nanoscale Regeneration’. Nanomedicine (Lond) 2015: 10, 677-680 

  4. Azeem A, English E, Biggs M, Jones E, Tripathi B, Henkel J, Vaquette C, Rooney N, Riley G, O’Riordan A, Cross G, Hutmacher D, Pandit A, Zeugolis D. ‘The influence of anisotropic nano- to micro-topography on in vitro and in vivoosteogenesis’ Nanomedicine (Lond) 2015: 10(5): 693-711 

  5. Mokarian-Tabari P, Vallejo-Giraldo C, Fernandez-Yague M, Cummins C, Morris MA, Biggs M.J. ‘Nanoscale neuroelectrode modification through self-assembly of block copolymers’. Journal of Materials Science: Materials in Medicine 2015: 26(120): 1-5

  6. English A, Azeem A, Biggs M, Jones E, Tripathi B, Basu N, Rooney N, Riley G, O'Riordan A, Cross G, Hutmacher D, Pandit A, Zeugolis DI. 'Data on in vitro and in vivo cell orientation on substrates with different topographies'. Data in Brief 2015: 5, 379-382

  7. Abbah SA, Delgado LM, Azeem A, Fuller K, Shologu N, Keeney M, Biggs MJ, Pandit A, Zeugolis DI. 'Harnessing Hierarchical Nano and Microfabrication Technologies for Musculoskeletal Tissue Engineering'. Advanced healthcare materials 2015: 16, 2488-2499

  8. Palma M, Hardy JG, Tadayyon G, Farsari M, Wind SJ, Biggs MJ. 'Advances in functional assemblies for regenerative medicine'. Advanced healthcare materials 2015: 16, 2500-2519

  9. Ryan CNM, Fuller KP, Larrañaga A, Biggs M, Bayon Y, Sarasua JR, Pandit A, Zeugolis DI. 'An academic, clinical and industrial update on electrospun, additive manufactured and imprinted medical devices'. Expert review of medical devices 2015: 12, 601-612

  10. Ballester-Beltrán J, Biggs M, Dalby MJ, Salmeron-Sanchez M, and Leal-Egaña A. ‘Sensing the Difference: The Influence of Anisotropic Surfaces on Cell Behavior’. Frontiers in Materials 2015: 2(39) 

  11. Lomas AJ, Sorushanova A, Ryan CNM, Sideri AI, Tsioli V, Fthenakis G.C, Tzora A, Skoufos I, Kelly J, Kearns S, Biggs MJ, Pandit A, Zeugolis DI. ‘The past, present and future in scaffold-based tendon treatments’. Advanced Drug Delivery Reviews 2015: 84, 257 -277

  12. Fernandez-Yague MA, Abbah SA, McNamara L, Zeugolis DI, Pandit A, Biggs MJ. ‘Biomimetic Approaches in Bone Tissue Engineering: Integrating Biological and Physicomechanical Strategies’ (Accepted) Advanced Drug Delivery Reviews 2015: 84 1-9

  13. Lobo J, See E, Biggs MJ, Pandit A. ‘An insight into morphometric descriptors of cell shape that pertain to regenerative medicine’. Journal of Tissue Engineering and Regenerative Medicine 2015: DOI: 10.1002/term.1994.

2014

  1. Chao J, Biggs MJ, Pandit A. ‘Diatoms: A Biotemplating Approach to Fabricating Drug Delivery Reservoirs’. (In Press) Expert Opinion on Drug Delivery 2014: 11(11): 1687-95

  2. Biggs MJ, Parisi-Capdevila E, Valejo-Giraldo C, Wind SJ. ‘Cellular response to ferroelectric PVDF-TrFE surfaces of varying polymer concentration’. Pharmaceutical nanotechnology 2014: 2(1): 42-48

  3. Cassidy JW, Roberts JN, Smith C, Robertson M, White K, Biggs MJ, Oreffo RO, Dalby MJ. ‘Osteogenic Lineage Restriction by Osteoprogenitors Cultured on Nanometric Grooved Surfaces – the Role of Focal Adhesion Maturation’. Acta Biomaterialia 2014: 10(3): 651-660

  4. Vallejo-Giraldo C, Kelly A, Biggs MJ. ‘Biofunctionalisation of electrically conducting polymers’. Drug Discovery Today. 2014: 19(1): 88-94.

  5. Biggs MJP, Vallejo-giraldo C, Pandit A. ‘Morphological modification of conducting polymers’. Journal of Tissue Engineering and Regenerative Medicine. 2014: 8, 137

2012

  1. McNamara LE, Burchmore R, Riehle MO, Herzyk P, Tsimbouri PM, Biggs MJP, Wilkinson CDW, Curtis ASG, Dalby MJ. ‘The role of microtopography in cellular mechanotransduction.’ Biomaterials. 2012: 33: 2835–2847 

  2. Santos LC, Biggs M, Wind S, Dustin M, Sheetz M. ‘Rigidity Sensing in T cells by Actin-Dependent Phosphorylation of Src Family Kinase Substrate   Cas-L’. Molecular Biology of the Cell. 2012: 23

2011

  1. ​Biggs MJ, Gondarenko A, Milone MC, Santos L, Wind SJ. ‘High resolution imaging of the immunological synapse and TCR microclustering through micro fabricated substrates’. Journal of the Royal Society Interface.  2011: 8(63): 1462-1471. (IF 4.907) Citation Number: 14

2010

  1. Biggs MJ, Dalby MJ. ‘Nanotopographical modification: a regulator of cellular function through focal adhesions.’ Nanomedicine 2010: 6(5): 619-633

  2. Biggs MJ, Dalby MJ. ‘Focal adhesions in osteoneogenesis.’ Journal of Engineering in Medicine 2010: 224 (Part H): 1441-145

  3. McNamara L, McMurray RJ, Biggs MJ, Kantawong F, Oreffo ROC, Dalby MJ. ‘Nanotopographical control of stem cell differentiation.’ Journal of Tissue Engineering 2010: 120623