New Collaborative Paper with Matthew Dalby and Team on Nanovibrational Stimulation of Stem Cells

There is a pressing clinical need to develop cell-based bone therapies due to a lack of viable, autologous bone grafts and a growing demand for bone grafts in musculoskeletal surgery. Such therapies can be tissue engineered and cellular, such as osteoblasts combined with a material scaffold. Because mesenchymal stem cells (MSCs) are both available and fast growing compared to mature osteoblasts, therapies that utilise these progenitor cells are particularly promising. Prof.. Matthew Dalby and team at the University of Glasgow have developed a nanovibrational bioreactor that can convert MSCs into bone-forming osteoblasts in 2D and 3D but the mechanisms involved in this osteoinduction process remain unclear. In this study, to elucidate this mechanism, we worked with Prof. Dalby with increasing vibrational amplitudes, from 30 nm (N30) to 90 nm (N90) amplitudes at 1000 Hz, to assess MSC metabolite, gene and protein changes.